We recommend that one 500 mg capsule of Berberine be taken between two to four times per day. It is strongly recommended that each capsule of Berberine taken per day be consumed at least 3 hours after the last one, as taking too much at once can increase the likelihood of gastrointestinal side effects.

Berberine should be taken along with or directly after a meal in order to maximize its beneficial effect on cholesterol.

When taken at normal doses Berberine is non-toxic and is usually well tolerated. The most common side effects reported are stomach upset, cramping, and diarrhea. These side effects are more likely to occur if more than 1 capsule is taken at a time.

Berberine should not be combined with any prescription medications without first consulting a physician as serious adverse reactions can occur when it is combined with certain drugs, specifically Phosphodiesterase inhibitors and microlide antibiotics.